Related Products of 84163-77-9, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 84163-77-9, Name is 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole, molecular formula is C12H13FN2O. In a Article，once mentioned of 84163-77-9
In order to target behavioral and psychological symptoms of dementia (BPSD), we used molecular modeling-assisted design to obtain novel multifunctional arylsulfonamide derivatives that potently antagonize 5-HT 6/7/2A and D2 receptors, without interacting with M 1 receptors and hERG channels. In vitro studies confirmed their antagonism of 5-HT7/2A and D2 receptors and weak interactions with key antitargets (M1R and hERG) associated with side effects. Marked 5-HT6 receptor affinities were also observed, notably for 6-fluoro-3-(piperidin-4-yl)-1,2-benzoxazole derivatives connected by a 3-4 unit alkyl linker with mono- or bicyclic, lipophilic arylsulfonamide moieties. N-[4-[4-(6-Fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]butyl] benzothiophene-2-sulfonamide (72) was characterized in vitro on 14 targets and antitargets. It displayed dual blockade of 5-HT6 and D2 receptors and negligible interactions at hERG and M1 receptors. Unlike reference antipsychotics, 72 displayed marked antipsychotic and antidepressant activity in rats after oral administration, in the absence of cognitive or motor impairment. This profile is particularly attractive when targeting a fragile, elderly BPSD patient population.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Related Products of 84163-77-9, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 84163-77-9, in my other articles.
Reference：
Piperidine – Wikipedia,
Piperidine | C5H17818N – PubChem