With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3970-68-1,4-Methylpiperidin-4-ol,as a common compound, the synthetic route is as follows.
Preparation of the amide: The acid chloride obtained above was dissolved in 3 ml of anhydrous THF, and 40 mg (0.340 mmol) of 4-methylpiperidine-4-ol [commercially available;Lit. example:.. JM McManus et al, J. Med Chem 1965, 8 (6), 766-776] and 100 mu (0.570 mmol) of N, N-diisopropylethylamine was added. Subsequently, the reaction mixture was stirred for about 16 h at RT.After the mixture was evaporated on a rotary evaporator to dryness, the crude product was purified by preparative HPLC (Method 5).After combining the product fractions, evaporation and drying of the residue under high vacuum, 113 mg (88% of theory..) Of the title compound, 3970-68-1
3970-68-1 4-Methylpiperidin-4-ol 15649174, apiperidines compound, is more and more widely used in various fields.
Reference£º
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; HAERTER, MICHAEL; DELBECK, MARTINA; KALTHOF, BERND; LUSTIG, KLEMENS; LINDNER, NIELS; KAST, RAIMUND; WASNAIRE, PIERRE; SUESSMEIER, FRANK; (372 pag.)TW2016/7950; (2016); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem