With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.657-36-3,4-Trifluoromethylpiperidine,as a common compound, the synthetic route is as follows.
General procedure: To a stirred solution of heterocyclic amines (1.1 mmol) and compound 23 (257.1 mg, 1 mmol) in anhydrous toluene (10 mL) wasadded Cs2CO3 (489.0 mg, 1.5 mmol), (¡À)-2,2′-Bis(diphenylphosphino)-1,1′-binaphthalene (62.0 mg, 0.1 mmol) and Palladium(II)acetate (25.0 mg, 0.1 mmol) at room temperature under argon. The mixture was refluxed for overnight, and then cooled to roomtemperature and filtered. The filtrate was diluted by EtOAc and washed with brine. The organic layer was concentrated and purified byFlash column chromatography (DCM/MeOH, 0-10%) to afford the crude target compounds 24b-j (50-64% yield).
657-36-3, As the paragraph descriping shows that 657-36-3 is playing an increasingly important role.
Reference£º
Article; Li; Wang; Wang, Bin; Liu, Mingliang; Lv, Kai; Tao, Zeyu; Ma, Chao; Ma; Han, Bing; Wang, Aoyu; Lu, Yu; Chinese Chemical Letters; (2019);,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem