With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.32018-96-5,1-Benzyl-4-methylpiperidin-3-one,as a common compound, the synthetic route is as follows.
To a stirred solution of 1-benzyl-4-methyl-piperidin-3-one (2.3 grams, 11.5 mmol), prepared by the methods of lorio, M.A. and Damia, G., Tetrahedron, 26, 5519 (1970) and Grieco et aL, Journal of the American Chemical Society, 107. 1768 (1985), (modified using 5% methanol as a co-solvent), both references are incorporated by reference in their entirety, dissolved in 23 mL of 2 M methylamine in tetrahydrofuran was added 1.4 mL (23 mmol) of acetic acid and the resulting mixture stirred in a sealed tube for 16 hours at room temperature. Triacetoxy sodium borohydride (4.9 grams, 23 mmol) was added and the new mixture stirred at room temperature in a sealed tube for 24 h, at which time, the reaction was quenched upon addition of 1 N sodium hydroxide (50 mL). The reaction mixture was then extracted 3 x
32018-96-5 1-Benzyl-4-methylpiperidin-3-one 12084828, apiperidines compound, is more and more widely used in various fields.
Reference£º
Patent; PFIZER PRODUCTS INC.; WO2008/29237; (2008); A2;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem