In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 177-11-7, name is 1,4-Dioxa-8-azaspiro[4.5]decane, introducing its new discovery. SDS of cas: 177-11-7
Chitin-derived dual O- and N-doped carbon nanofibrous microspheres are reported to promote oxidative double carbonylation of alkanes with amines. Bulk chemicals such as alkanes and CO can be easily transformed to various value-added alkyl alpha-ketoamides. Notably, the porous carbon nanofibrous microspheres with large surface area could supply potential adhesion sites for amines, which inhibited the oxidative decomposition of amines to promote this transformation. Sustainable development is one of the cores of modern chemistry. Alkanes are the principal components of petroleum, and CO is one of the most important C1 building blocks. They are the basic raw materials in the chemical industry. Attempting to efficiently convert feedstock into value-added chemicals always attracts the attention of chemists. On the other hand, natural and abundant renewable biomass macromolecules, such as cellulose and chitin, have attracted great attention because of their fascinating structures and unique properties. In this paper, we report that chitin-derived dual O- and N-doped carbon nanofibrous microspheres promote oxidative double carbonylation of alkanes with amines for the preparation of various alkyl alpha-ketoamides. Compared with traditional methods, this strategy has some outstanding advantages: readily available substrates, high selectivity, and the absence of metals. Here, dual O- and N-doped carbon nanofibrous microspheres (CNMs) promoting the chemical transformation of alkane with CO have been achieved smoothly. Efficient conversion of bulk chemicals is of great significance in chemical synthesis. Carbonylation involving CO is an important process for constructing carbonyl compounds in industry and academia, among which stands out metal-catalyzed carbonylation. However, the strong coordination ability and reducibility of CO usually lower the activity of metal catalysts. Hence, it becomes urgent to explore novel conversion strategies, such as fabricating new materials to replace traditional catalysts. In this work, we show that chitin-derived CNMs mediate oxidative double carbonylation of alkanes for the preparation of various alkyl alpha-ketoamides. In our findings, the porous CNM with large surface area could supply potential adhesion sites for amines, which inhibited the oxidative decomposition of amines to promote this transformation. Notably, to our knowledge, oxidative double carbonylation of the alkane C(sp3)?H bond has not yet been reported.
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 177-11-7 is helpful to your research. SDS of cas: 177-11-7
Reference：
Piperidine – Wikipedia,
Piperidine | C5H7654N – PubChem