New learning discoveries about 892493-65-1

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.892493-65-1,tert-Butyl piperidine-4-carboxylate hydrochloride,as a common compound, the synthetic route is as follows.

892493-65-1, A solution of ethyl 6-chloro-5-cyano-2-methyhiicotinate (6.00 g, 26.7 mmol), tert-butyl piperidine-4-carboxylate hydrochloride (6.51, 29.4 mmol) and DBPEA (23.3 mL, 134 mmol) in DMA (50 mL) were heated to 80 ¡ãC for 2 h. After cooling to r.t, the reaction mixture was diluted with EtOAc (300 mL), washed with saturated NH4Cl (4 x 50 mL), brine (50 mL), dried (MgSO4), passed through silica gel and concentrated. Flash chromatography produced ethyl 6-(4-(tert-butoxycarbonyl)piperidm-l-yl)-5-cyano-2-memylnicotinate as a solid. Yield: 8.85 g (89 percent). EPO 1H NMR (400 MHz, CDCl): delta 1HNMR (400 MHz, CDCl5): delta 1.37 (3H, t, J= 7.1 Hz), 1.45 (9H, s), 1.75-1.84 (2H, m), 1.99-2.03 (2H, m), 2.49-2.57 (IH, m), 2.72 (3H, s), 3.24-3.31 (2H, m), 4.31 (2H, q, J= 7.1 Hz), 4.55-4.60 (2H, m), 8.34 (IH, s). MS m/z: 374 (M+l).

892493-65-1 tert-Butyl piperidine-4-carboxylate hydrochloride 42614227, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; ASTRAZENECA AB; WO2007/8140; (2007); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem