With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3970-68-1,4-Methylpiperidin-4-ol,as a common compound, the synthetic route is as follows.,3970-68-1
Compound 13-6 (0.250g, 0.5mmol), 4- hydroxypiperidine (0.125g, 1.1mmol) was dissolved in 1,2-dichloroethane (12ml), the protection purged with nitrogen, stirred 30min, was added NaBH (OAc 3(1.151g, 5.4mmol), reacted at room temperature overnight. TLC showed the reaction of the starting material was completed, and saturated sodium bicarbonate solution and DCM (50ml / 40ml) were added, and the aqueous phase was extracted with DCM (50ml ¡Á 2). The phase was dried over anhydrous sodium sulfate, concentrated, and then purified by thin layer chromatography to yield 0.090 g of pure product, yield: 32%.
The synthetic route of 3970-68-1 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Suzhou Yuanzhi Pharmaceutical Technology Co., Ltd.; Chen Li; Zhao Jian; (48 pag.)CN109896991; (2019); A;,
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