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We report the development of molecular hybrids in which a nitrate group serving as nitric oxide (NO) donor is covalently joined to sigma receptor ligands to give candidates for double-targeted cancer therapy. The compounds have been evaluated in radioligand binding assay at both sigma receptors and selected compounds tested for NO release. Compounds 9, 15, 18, 19, and 21 were subjected to MTT test. Compound 15 produced a significant reduction of MCF-7 and Caco-2 cellular viability with comparable IC50 as doxorubicin, being also not toxic for fibroblast HFF-1 cells. Compound 15 has shown a sigma1 receptor antagonist/sigma2 receptor agonist profile. Two derivatives of compound 15 lacking the nitrate group did not induce a reduction of MCF-7 cellular

Because enzymes can increase reaction rates by enormous factors and tend to be very specific, Safety of 4-Amino-1-benzylpiperidine, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 50541-93-0

Reference：
Piperidine – Wikipedia,
Piperidine | C5H12110N – PubChem