5570-78-5, 1-Isopropylpiperidin-4-ol is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
5570-78-5, To a solution of l-(l-methylethyl)piperidin-4-ol (103 mg, 0.724 mmol) in THF (3 ml) under an atmosphere of nitrogen was added KO1Bu (136 mg, 1.21 mmol). The mixture was stirred for 15 min at room temperature before 2-chloro-6-methyl-5,6,7,8-tetrahydro-l,6- naphthyridine-3-carbonitrile (100 mg, 0.483 mmol) was added. The resulting mixture was heated to 90 0C by microwave irradiation and stirred for 15 min. After cooling to RT, the reaction mixture was quenched by pouring onto saturated aqueous NaHCO3 , extracted with EtOAc (3 x 20 ml), dried (Na2SO4), filtered and concentrated at reduced pressure. The residue was purified by FCC (SiO2, eluting with 95:5 chloroform / MeOH) to give the title compound (36 mg, 24 %) as yellow oil. LCMS data: Calculated MH+ (315); Found 94 % (MH+) m/z 315, Rt = 4.78 min.1H NMR (400 MHz, MeOD) delta ppm 7.73 (1 H, s), 5.29 – 5.36 (1 H, m), 3.55 (2 H, s), 2.93 – 3.07 (5 H, m), 2.78 – 2.84 (4 H, m), 2.48 (3 H, s), 2.10 – 2.20 (2 H, m), 1.95 – 2.04 (2 H, m), 1.20 (6 H, d, J=6.6 Hz).
As the paragraph descriping shows that 5570-78-5 is playing an increasingly important role.
Reference£º
Patent; EVOTEC NEUROSCIENCES GMBH; WO2009/121812; (2009); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem