Application of 3515-49-9, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.3515-49-9, Name is 3-(Piperidin-4-ylmethyl)-1H-indole, molecular formula is C14H18N2. In a Article，once mentioned of 3515-49-9
Pin1 (Protein interacting with NIMA1) is a cis?trans isomerase and promotes the amide bond rotation of phosphoSer/Thr-Pro motifs in its substrates. Inhibition of Pin1 might be a novel strategy for developing anticancer agents. Herein, a series of pyrimidine derivatives were synthesized and their Pin1 inhibitory activities were evaluated. Among them, four compounds (2a, 2f, 2h and 2l) displayed potent inhibitory activities against Pin1 with IC50 values lower than 3 muM. This series of pyrimidine-based inhibitors presented time-dependent inhibition against Pin1. The structure?activity relationships on the 2-, 4- and 5-positions of the pyrimidine ring were analyzed in details, which would facilitate further exploration of new Pin1 inhibitors.
A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 3515-49-9
Reference：
Piperidine – Wikipedia,
Piperidine | C5H16944N – PubChem