37675-20-0, (R)-(Piperidin-3-yl)methanol is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
TEA (1.76 g, 17.4 mmol, 2.42 mL) was added to a solution of [(3R)-3 -piped dyl]methanol (1.0 g, 8.68 mmol) in THF (25.0 mL), followed by the addition of a solution of B0C2O (1.89 g, 8.68 mmol, 1.99 mL) in THF (5 mL) at 15 C. The mixture was stirred at 15 C for 12 hours. The solvent was removed under vacuum and the residue dissolved in ethyl acetate (50 ml) and H2O (30 mL). The solution was acidified with HC1 (6 M) to pH~6 and the layers separated. The organics were washed with brine (3 x 50 mL) and the combined organics concentrated to dryness to give tert- butyl (3R)-3-(hydroxymethyl)piperidine-l-carboxylate (1.68 g, 7.80 mmol, 89.9% yield, 100% purity) as colorless crystals. MR (400MHz, chloroform-d) delta = 3.73 (br s, 2H), 3.51 (br d, J = 6.8 Hz, 2H), 3.05 (br s, 2H), 1.83 – 1.71 (m, 2H), 1.62 (br s, 1H), 1.46 (s, 9H), 1.44 – 1.37 (m, 1H), 1.35 – 1.22 (m, 1H).
37675-20-0, The synthetic route of 37675-20-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; MIRATI THERAPEUTICS, INC.; ARRAY BIOPHARMA, INC.; FISCHER, John, P.; FELL, Jay, Bradford; BLAKE, James, F.; HINKLIN, Ronald, Jay; MEJIA, Macedonio, J.; HICKEN, Erik, James; CHICARELLI, Mark, Joseph; GAUDINO, John, J.; VIGERS, Guy, P.A.; BURGESS, Laurence, E.; MARX, Matthew, Arnold; CHRISTENSEN, James, Gail; LEE, Matthew, Randolf; SAVECHENKOV, Pavel; ZECCA, Henry, J.; (529 pag.)WO2017/201161; (2017); A1;,
Piperidine – Wikipedia
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