236406-39-6, 8-Boc-2,8-Diazaspiro[4.5]decane is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Step A: tert-butyl 2- [6-(Methylsulfonyl)pyridin-3 -yll-2,8-diazaspiro [4.5 ldecane-8-carboxvlate:A stirred solution of 5-bromo-2-(methylsulfonyl)pyridine (0.1 g, 0.5 mmol), tert-butyl 2,8- diazaspiro [4.5] decane-8-carboxylate (commercially available from multiple vendors, for example AstaTech, Inc. catalog 11097; 0.1 g, 0.4 mmol), Pd2dba3 (0.02 g, 0.02 mmol), 5-Phos (0.03 g, 0.08 mmol), and Cs2CO3 (0.4 g, 1.2 mmol) in THF (20 mL) were heated to reflux for 12h. The solution was diluted with H20 and stirred vigorously. The organic layer was removed,dried over MgSO4, filtered and concentrated giving rise to an oil. The oil was purified using a 25 g Biotage SNAP cartridge (7-60% EtOAc:hexanes) giving rise to title compound. LCMS: m/z 396.20 (M+H)., 236406-39-6
As the paragraph descriping shows that 236406-39-6 is playing an increasingly important role.
Reference£º
Patent; MERCK SHARP & DOHME CORP; TANG, Haifeng; PIO, Barbara; JIANG, Jinlong; PASTERNAK, Alexander; DONG, Shuzhi; FERGUSON, Ronald Dale, II; GUO, Zack Zhiqiang; CHOBANIAN, Harry; FRIE, Jessica; GUO, Yan; WU, Zhicai; YU, Yang; WANG, Ming; WO2015/17305; (2015); A1;,
Piperidine – Wikipedia
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