98977-34-5,98977-34-5, 1-tert-Butyl 3-ethyl 4-oxopiperidine-1,3-dicarboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
NaH 60percent in oil (0.62g, 15.48mmol) was added portionwise to a solution of 1,3-(4-oxo-piperidine)-dicarboxylic acid, 1-(1,1-dimethylethyl) 3-ethyl ester (2g, 7.37mmol) suspended in THF (20ml) cooled at 0¡ãC. The mixture was stirred for 30 minutes at 0¡ãC and then allowed to warm to ambient temperature and stirred for a further 1 hour. 3- fluorobenzylbromide (1.36ml, 11.06mmol) was added and the resulting solution was stirred at room temperature overnight. Water and then EtOAc were added. The organic layer was extracted, washed with brine, dried over MgS04, filtrered and concentrated. The residue (2.78g) was purified by Normal phase on irregular SiOH (15-40muiotaeta, 300g); mobile phase (85percent heptane, 15percent EtOAc). The pure fractions were collected and the solvent was evaporated, yielding lg (35.7percent) of intermediate 88.
As the paragraph descriping shows that 98977-34-5 is playing an increasingly important role.
Reference£º
Patent; JANSSEN PHARMACEUTICA NV; GUILLEMONT, Jerome, Emile, Georges; MOTTE, Magali, Madeleine, Simone; LANCOIS, David, Francis, Alain; THOMAS, Sebastien, Robert, Gaston; BALEMANS, Wendy, Mia, Albert; WO2013/160431; (2013); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem