New explortion of 1-Boc-4-Cyanopiperidine

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Six tetrazole analogues of GABA-mimetic compounds were synthesized. In vitro only two compounds, analogues of GABA and isoguvacine, showed a weak affinity for GABA-A and GABA-B receptors. In vivo compounds were inactive in a psychopharmacological screening in mice. The results were interpreted in terms of intercharge distance, electronic delocalisation and ability of membrane crossing.

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Reference：
Piperidine – Wikipedia,
Piperidine | C5H15801N – PubChem