1001353-92-9, (R)-1-Methylpiperidin-3-amine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of Int 13 (342 mg, 1 .001 mmol) and (R)-1 -methylpiperidin-3-amine (149 mg, 1 .301 mmol) in DMF (8 ml.) was added DIPEA (0.524 ml_, 3.00 mmol), HOBt (169 mg, 1 .101 mmol) and EDC (249 mg, 1 .301 mmol). The solution was stirred at RT overnight. The reaction mixture was diluted with 5% Na2CC>3 solution and extracted with EtOAc. The organic layer was washed twice with 5% Na2CC>3 solution, then brine. A white precipitate which formed between the layers was filtered off. The remaining organic extract was dried over Na2S04, filtered and evaporated to give an off-white solid after trituration with DCM. This crude product was combined with the first precipitate and further purified by crystallization from hot MEK to provide the title compound as white crystalline solid. 1 H NMR (400 MHz, DMSO-d6) d (ppm) 7.98 (d, J = 8.0 Hz, 1 H), 7.91 (s, 1 H), 7.53 (s, 1 H), 6.09 (s, 1 H), 4.54 (d, J = 1 .9 Hz, 2H), 3.81 – 3.66 (m, 1 H), 2.66 – 2.57 (m, 1 H), 2.48 – 2.45 (m, overlapping with DMSO signal, 1 H) 2.13 (s, 3H), 1 .98 – 1 .87 (m, 1 H), 1 .86 – 1 .76 (m, 1 H), 1 .71 – 1 .60 (m, 2H), 1 .58 (s, 6H), 1 .52 – 1 .38 (m, 1 H), 1 .27 – 1 .1 1 (m, 1 H). LC-MS: Rt = 0.69 min; MS m/z [M+H]+ 438.2
1001353-92-9, The synthetic route of 1001353-92-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; NOVARTIS AG; FARADY, Christopher; GOMMERMANN, Nina; JANSER, Philipp; MACKAY, Angela; MATTES, Henri; STIEFL, Nikolaus Johannes; VELCICKY, Juraj; (148 pag.)WO2020/21447; (2020); A1;,
Piperidine – Wikipedia
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