477600-70-7, (3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
4,6-dichloro-5-methoxy-pyrimidine (0.66g, 3.68mmol) and (3R, 4R) -1- benzyl -N, 4- dimethyl-piperidin-3-amine (0.80g, 3.68 mmol) was dissolved in DMF (5mL), was added potassium carbonate (1.02g, 7.36mmol), 70 reaction was stirred overnight under nitrogen.Water was added (100 mL) to quench the reaction, extracted with ethyl acetate (80mL ¡Á 3), the organic phase was washed with water (50 mL) washed with saturated aqueous sodium chloride solution (50 mL), dried over anhydrous sodium sulfate, and concentrated under reduced pressure, subjected to column chromatography (eluent: PE / EtOAc (v / v) = 1/1), to give the product 1.13g, yield: 85.0%.
477600-70-7, 477600-70-7 (3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine 44630604, apiperidines compound, is more and more widely used in various fields.
Reference£º
Patent; Guangdong East Sunshine Pharmaceutical Co., Ltd.; Liu, Bing; Huang, Jiuzhong; Ren, Xingye; Li, Zhi; Zhang, Yingjun; Zhang, Changchun; (55 pag.)CN105566321; (2016); A;,
Piperidine – Wikipedia
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