A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, Safety of 3-(Boc-aminomethyl)piperidine, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 142643-29-6, Name is 3-(Boc-aminomethyl)piperidine, molecular formula is C11H22N2O2. In a Article, authors is Burger, Matthew T.，once mentioned of 142643-29-6
Proviral insertion of Moloney virus (PIM) 1, 2, and 3 kinases are serine/threonine kinases that normally function in survival and proliferation of hematopoietic cells. As high expression of PIM1, 2, and 3 is frequently observed in many human malignancies, including multiple myeloma, non-Hodgkins lymphoma, and myeloid leukemias, there is interest in determining whether selective PIM inhibition can improve outcomes of these human cancers. Herein, we describe our efforts toward this goal. The structure guided optimization of a singleton high throughput screening hit in which the potency against all three PIM isoforms was increased >10,000-fold to yield compounds with pan PIM Kis < 10 pM, nanomolar cellular potency, and in vivo activity in an acute myeloid leukemia Pim-dependent tumor model is described. I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 142643-29-6, help many people in the next few years.Safety of 3-(Boc-aminomethyl)piperidine
Reference：
Piperidine – Wikipedia,
Piperidine | C5H16846N – PubChem