With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.19733-56-3,4-(Piperidin-3-yl)aniline,as a common compound, the synthetic route is as follows.
To a mixture of 4-(piperidin-3-yl) aniline (Compound 16) (0.5 g) in acetone (5 mL), succinic acid (0.36 g) was charged at reflux temperature. The reaction mass was stirred at reflux temperature for 30 minute. The reaction mass was cooled to 20-25C and stirred further for 3 h. The solid obtained was filtered, washed with acetone (3 mL) and dried under vacuum at 50-55C to afford the titled compound (Yield: 0.63 g; HPLC Purity: >95.0% ).
19733-56-3, As the paragraph descriping shows that 19733-56-3 is playing an increasingly important role.
Reference£º
Patent; TEVA PHARMACEUTICALS USA, INC.; TEVA PHARMACEUTICALS INTERNATIIONAL GMBH; LUTHRA, Parven, Kumar; VASOYA, Sanjay, Lakhabhai; PATIL, Bhatu, Tumba; TANEJA, Amit, Kumar; SRIVASTAV, Naveen, Chandra; SINGH, Rinku; (63 pag.)WO2019/36441; (2019); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem