7149-42-0, (1-Methylpiperidin-4-yl)methanamine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
7149-42-0, The intermediate 3-cyano-4-(4-methoxy-4-methyl-piperidin-1-yl)-2-oxo-1,2-dihydro-1,7-naphthyridine-6-carboxylic acid (200 mg, 0.58mmol, 1.0eq), was dissolved in anhydrous N, N- dimethylacetamide (2mL), DIPEA (226.3mg, 1.75mmol, 3.0eq) and HATU (333.1mg, 0.88mmol, 1.5eq), was added and stirred at room temperature 0.5 ~ 1h. a solution of (1-methyl-piperidin-4-yl)methanamine (150mg, 1.17mmol, 2.0eq), the reaction at room temperature 1h. LC-MS monitoring starting material still remaining supplemented with (1-methyl-piperidin-4-yl) methanamine (150mg, 1.17mmol, 2.0eq), the reaction was continued 2h, and purified by preparative HPLC (0.1% aqueous trifluoroacetic acid 30:: acetonitrile = 70) to give product (68.8mg, yield: 20.7%).
As the paragraph descriping shows that 7149-42-0 is playing an increasingly important role.
Reference£º
Patent; Nanjing Yaojie Good Health Biological Technology Co., Ltd.; Wu Yongqian; Li Lin; Yang Xiaoju; (118 pag.)CN109575016; (2019); A;,
Piperidine – Wikipedia
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