134441-61-5, (R)-N-Boc-Piperidine-2-methanol is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
The (2R)-piperidin-2-ylmethanol used as starting material was prepared as follows: Trifluoroacetic acid (3 ml) was carefully added to a stirring solution of tert-butyl (2R)-2- (hydroxymethyl)piperidine-l-carboxylate (1.15 g, obtained as described in Tetrahedron, 58 (2002), 1343 – 1354) in DCM (3 ml) and stirred at room temperature for 1 hour. Volatiles were removed in vacuo and the oil thus obtained dissolved in methanol (60 ml), and neutralized by addition of MP-Carbonate resin (polymer supported carbonate reagent ex. Argonaut Technologies Inc.) (approximately 1 g) whilst stirring at room temperature for 2 hours. The resin was filtered, washed with methanol (3 x 30 ml) and the filtrate concentrated. The resulting oil was dissolved in DCM (30 ml) and dried (MgSO4) before filtration and solvent removal to afford a grey oil (615 mg, 100%); NMR spectrum 1.44 – 1.51 (m, 2H), 1.61 (m, IH), 1.70 – 1.78 (m, 3H), 2.84 (m, IH), 3.03 (m, IH), 3.21 (d, IH), 3.49 (m, IH), 3.57 (dd, IH), 5.01 (bs, IH), 7.65 (bs, IH): Mass spectrum M+ 116., 134441-61-5
134441-61-5 (R)-N-Boc-Piperidine-2-methanol 6933953, apiperidines compound, is more and more widely used in various fields.
Reference£º
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2006/92574; (2006); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem