Reference of 206989-61-9, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 206989-61-9, Name is tert-Butyl 4-acetylpiperidine-1-carboxylate, molecular formula is C12H21NO3. In a Article，once mentioned of 206989-61-9
Fragment assembly has shown promise for discovering small-molecule antagonists for difficult targets, including protein-protein interactions. Here, we describe a process for identifying a 60 nM inhibitor of the interleukin-2 (IL-2)/IL-2 receptor (IL-2Ralpha) interaction. By use of fragment-based approaches, a compound with millimolar affinity was evolved to a hit series with low micromolar activity, and these compounds were optimized into a lead series with nanomolar affinity. Fragment assembly was useful not only for hit identification, but also for lead optimization. Throughout the discovery proces, biophysical methods and structural biology demonstrated that compounds bound reversibly to IL-2 at the IL-2 receptor binding site.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Reference of 206989-61-9, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 206989-61-9, in my other articles.
Reference：
Piperidine – Wikipedia,
Piperidine | C5H18233N – PubChem