With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.146093-46-1,4-(Aminoethyl)-1-N-Boc-piperidine,as a common compound, the synthetic route is as follows.
To a solution of 2-(4-oxo-3,4-dihydropyrido[3,4-d]pyrimidin-2-yl)benzofuran-7- carboxylic acid (1.0 eq) and 4-(2-Amino-ethyl)-piperidine-l -carboxylic acid tert-butyl ester (1.1 eq) in Nu,Nu-dimethylformamide were added N,N-diisopropylethylamine (2.0 eq) and HATU (1.2 eq). The mixture was allowed to stir for 30 min. It was diluted with brine and extracted with ethyl’ acetate twice. The combined organic extract was washed with brine twice and dried over magnesium sulfate (or extracted with UCT SPE CUBCX -cartr-idge)r4t- was concentrated- and- purified by combi-flashr~or~preparative^ HPLC., 146093-46-1
As the paragraph descriping shows that 146093-46-1 is playing an increasingly important role.
Reference£º
Patent; DONG-A SOCIO HOLDINGS CO., LTD.; KIM, Myeong-seop; PARK, Taesun; YOON, Taeyoung; YANG, Seung Min; KIM, Hae-Sun; KIM, Jun Gyu; (285 pag.)WO2016/68580; (2016); A2;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem