With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.54012-73-6,Piperidin-3-amine,as a common compound, the synthetic route is as follows.
54012-73-6, In a sample bottle with stopper with a volume of 20 ml,1.00 g (10.0 mmol) of racemic 3-aminopiperidine,2.65 g (10.0 mmol) of N-p-toluyl-D-glutamic acid,5.55 g of methanol,And 0.97 g of water, and the mixture was heated to 60 C. for dissolution,10 mg of N-p-toluyl-D-glutamate of (S) -3-aminopiperidine was added.After cooling to 10 C.,After filtering the precipitated crystals,And dried to obtain 1.57 g of a salt.The optical purity of 3-aminopiperidine contained in the salt was 95.5% e. E. (S form).A portion of this salt was collected to quantify 3-aminopiperidine,The content rate is 27.5%This salt,It was confirmed to be a 1: 1 salt of 3-aminopiperidine and Np-toluyl-D-glutamic acid.Yield 43%.
The synthetic route of 54012-73-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; TORAY FINE CHEMICALS CO LTD; FUJINO, TOSHIHIRO; HIRAGA, HISAFUMI; (9 pag.)JP5838590; (2016); B2;,
Piperidine – Wikipedia
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