With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.675-20-7,Piperidin-2-one,as a common compound, the synthetic route is as follows.
10300] To a solution of compound 1 (31.00 g, 312.72 mmol) in CH3CN (500 mE) was added TEA (63.29 g, 625.44 mmol), 13oc20 (88.73 g, 406.54 mmol), DMAP (1.91 g, 15.64 mmol) in portions under N2. The mixture was stirred at 18 C. for 16 hours. TLC showed the reaction was completed. The mixture was concentrated in reduced pressure at 35 C. The residue was purified by silica gel chromatography (PE/EA30/1 to 5/1) to afford compound 2 (41.90 g, 210.29 mmol, 67.25% yield) as yellow oil. LCMS:200 [M+1]., 675-20-7
675-20-7 Piperidin-2-one 12665, apiperidines compound, is more and more widely used in various fields.
Reference£º
Patent; Novira Therapeutics, Inc.; Hartman, George D.; Kuduk, Scott; (85 pag.)US2016/272599; (2016); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem