159635-49-1, tert-Butyl 4-methylenepiperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,159635-49-1
To a degassed, cooled (0¡ãC) sample of 11 (1.7 g) was added 9-BBN (17.5 mL of a 0.5 M in THF). The cooling bath was removed and the solution was stirred for 1.5 h at RT. The resulting solution was added, at RT, to a mixture of the sulfone 10 (0.27 g), Pd(dppf)Cl2 (20 mg), triphenyl arsine (25 mg), DMF (2.0 mL), water (0.18 mL) and Cs2CO3 (0.33 g). The resulting mixture was heated at 60¡ãC for 3 h 45 min. After cooling to RT and pouring into water, the pH was adjusted to 11 with 10 percent NaOH and mixture was extracted with EtOAc (3 * 25 mL). The combined organic extracts were dried with brine and MgSO4, filtered and evaporated to give a crude which was further purified by preparative plate chromatography (2000 muM plate; silica adsorbent; 1:1 EtOAc:hexanes eluant) to give the product 12 as a white foam (0.28 g) in 77 percent yield.
159635-49-1 tert-Butyl 4-methylenepiperidine-1-carboxylate 2756808, apiperidines compound, is more and more widely used in various fields.
Reference£º
Patent; SCHERING CORPORATION; EP1091956; (2004); B1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem