With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.252882-61-4,Spiro[indoline-3,4′-piperidin]-2-one,as a common compound, the synthetic route is as follows.
Process 2Production of 1′-{2-(2-trifluoromethoxyphenoxy)acetyl}spiro(indole-3,4′-piperidine)-2(1H)-oneTo a methylene chloride solution (5 mL) of spiro (indole-3,4′-piperidine)-2(1H)-one (50.0 mg, 0.247 mmol), 2-trifluoromethoxyphenoxyacetic acid (58.4 mg, 0.247 mmol), PyBOP (142 mg, 0.272 mmol), and diisopropylethylamine (63.9 mg, 0.494 mmol) were added sequentially at room temperature. The mixture was stirred at the same temperature for 5 hours. The reaction solution was added with water and then extracted with chloroform. The organic layer was dried with anhydrous sodium sulfate, followed by a vacuum concentration. The resultant residue was purified by preparative thin-layer chromatography (hexane:ethyl acetate=1:2) and 1′-{2-(2-trifluoromethoxyphenoxy)acetyl}spiro(indole-3,4′-piperidine)-2(1H)-one (33.0 mg, 31.8%) was obtained as a colorless amorphous solid.1H-NMR (400 MHz, CDCl3) delta; 1.83-1.91 (m, 4H), 3.80-3.86 (m, 1H), 3.90-3.97 (m, 1H), 4.03 (quint, J=6.8 Hz, 1H), 4.24-4.30 (m, 1H), 4.79 (d, J=12.9 Hz, 1H), 4.87 (d, J=12.9 Hz, 1H), 6.91 (t, J=7.8 Hz, 1H), 7.00-7.30 (m, 7H), 8.58 (s, 1H).IR(ATR); 3217,1711,1632,1471,1223,755 cm-1.EI-MS m/z; 420(M+)., 252882-61-4
As the paragraph descriping shows that 252882-61-4 is playing an increasingly important role.
Reference£º
Patent; KOWA CO., LTD.; US2008/306102; (2008); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem