With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.37675-18-6,(S)-Ethyl piperidine-3-carboxylate,as a common compound, the synthetic route is as follows.
4.3.40 Ethyl (S)-1-(ethoxymethyl)piperidine-3-carboxylate, (S)-10 K2CO3 (2.8?g, 20?mmol) was added to a solution of ethyl nipecotate (3.2?mL, 20?mmol) in EtOH (7.0?mL, 0.12?mol) at 0?C. After 15?min paraformaldehyde (PFA) (0.63?g, 20?mmol) was added, and the mixture was stirred at 25?C for 6?h. The mixture was diluted with Et2O and filtered. The filtrate was concentrated under reduced pressure. The crude product was purified by distillation (Kugelrohr distillation) at 130?C (0.4?Torr) to obtain the product N,O-acetal (rac-10) as a colorless oil (3.1?g, 71%). Analytical data corresponds to those of rac-10 except [alpha]D 20 = +13.3 (c?=?2.0, DCM).
37675-18-6, 37675-18-6 (S)-Ethyl piperidine-3-carboxylate 187784, apiperidines compound, is more and more widely used in various fields.
Reference£º
Article; Toth, Krisztian; Hoefner, Georg; Wanner, Klaus T.; Bioorganic and Medicinal Chemistry; vol. 26; 22; (2018); p. 5944 – 5961;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem