With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3970-68-1,4-Methylpiperidin-4-ol,as a common compound, the synthetic route is as follows.
l-(6-Chloropyrazin-2-yl)-3,3-dimethyl-6-(2-methylpyrimidin-5-yl)indolin-2-one (52 mg, 142 mupiiotaomicron, Eq: 1, Example 6a), 4-methylpiperidin-4-ol (24.6 mg, 213 mupiiotaomicron, Eq: 1.5) and potassium carbonate (39.3 mg, 284 mupiiotaomicron, Eq: 2) were combined with acetonitrile (711 mu). The reaction mixture was heated to 100 C and stirred for 3 days until no starting material was left. The residue was purified by chromatography on silica gel to afford the desired product as a light yellow foam (63 mg, 99 %). MS (m/z) = 445.2 [M + H]+.
3970-68-1, As the paragraph descriping shows that 3970-68-1 is playing an increasingly important role.
Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; GAUFRETEAU, Delphine; KOLCZEWSKI, Sabine; PLANCHER, Jean-Marc; STOLL, Theodor; (99 pag.)WO2017/76842; (2017); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem