Downstream synthetic route of 103816-19-9

103816-19-9, As the paragraph descriping shows that 103816-19-9 is playing an increasingly important role.

103816-19-9, [1,4′-Bipiperidine]-1′-carbonyl chloride is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

SN-38B-11 (1.22 g, 2.08 mmol, yield 89%, enantiopurity 99.8%ee) was obtained from SN-38 (0.91 g, 2 .32 mmol) synthesized in Example 9 by the reported procedure (Sawada, S.; Okajima, S.; Aiyama, R.; Nokata, K.; Furuta, T.; Yokokura, T.; Sugino, E.; Yamaguchi, K.; Miyasaka, T. Chem. Pharm. Bull. 1991, 39, 1446.).Chiral HPLC operation conditions Column: DAICEL CHIRALCEL OD-H, 0.46cmID¡Á25cm (No.ODH0CE-AK031) Guard cartridge: DAICEL CHIRALCEL OD-H, 0.4cmIDxlcm Injection amount:10mug/10muL Temperature: constant temperature about 40C Flow rate: 1mL/min Mobile phase: dimethylamine : hexane : ethanol mixture(1 : 250 : 250) Detect: 254nm

103816-19-9, As the paragraph descriping shows that 103816-19-9 is playing an increasingly important role.

Reference£º
Patent; Kabushiki Kaisha Yakult Honsha; EP1378505; (2004); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem