Reference of 91419-52-2, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 91419-52-2, Name is 1-Boc-4-Cyanopiperidine, molecular formula is C11H18N2O2. In a Article，once mentioned of 91419-52-2
The Mediator complex-associated cyclin-dependent kinase CDK8 has been implicated in human disease, particularly in colorectal cancer where it has been reported as a putative oncogene. Here we report the discovery of 109 (CCT251921), a potent, selective, and orally bioavailable inhibitor of CDK8 with equipotent affinity for CDK19. We describe a structure-based design approach leading to the discovery of a 3,4,5-trisubstituted-2-aminopyridine series and present the application of physicochemical property analyses to successfully reduce in vivo metabolic clearance, minimize transporter-mediated biliary elimination while maintaining acceptable aqueous solubility. Compound 109 affords the optimal compromise of in vitro biochemical, pharmacokinetic, and physicochemical properties and is suitable for progression to animal models of cancer.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Reference of 91419-52-2, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 91419-52-2, in my other articles.
Reference：
Piperidine – Wikipedia,
Piperidine | C5H15782N – PubChem