With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.479630-08-5,1-Boc-4-(2-Ethoxycarbonyl-acetyl)piperidine,as a common compound, the synthetic route is as follows.
Tert-butyl 4-(3-ethoxy-3-oxopropanoyl)piperidine-l-carboxylate (1.07 g, 3.58 mmol, 1.5 eq), 4-ethoxy- lH-indazol-3-amine (423 mg, 2.39 mmol, 1 eq) and potassium phosphate (1.01 g, 4.78 mmol, 2 eq) were suspended in l-methoxy-2-propanol (10 mL) in a 20 mL microwave vial. The vial was capped and the mixture was heated in a microwave to 180C for 15 min. After cooling to RT, the suspension was diluted with 20 mL dichloromethane/methanol (4: 1), filtered through a short pad of silica gel with 100 mL dichloromethane/methanol (4: 1) and evaporated in vacuo. The residue was triturated with MTBE (15 mL), filterered, washed with MTBE (2 mL) and dried for 16 h at 50C in vacuo to yield the title compound (161 mg, 15% of theory). LC-MS (Method IB): Rt = 1.11 min, MS (ESIPos): m z = 413 [M+H]+
479630-08-5, 479630-08-5 1-Boc-4-(2-Ethoxycarbonyl-acetyl)piperidine 6618868, apiperidines compound, is more and more widely used in various fields.
Reference£º
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; HASSFELD, Jorma; KINZEL, Tom; KOeBBERLING, Johannes; CANCHO-GRANDE, Yolanda; BEYER, Kristin; ROeHRIG, Susanne; KOeLLNBERGER, Maria; SPERZEL, Michael; BURKHARDT, Nils; SCHLEMMER, Karl-Heinz; STEGMANN, Christian; SCHUHMACHER, Joachim; WERNER, Matthias; ELLERMANN, Manuel; WO2015/67549; (2015); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem