Synthetic Route of 58333-75-8, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.58333-75-8, Name is 4-(2-Methoxyphenyl)piperidine, molecular formula is C12H17NO. In a article，once mentioned of 58333-75-8
To obtain an optimized T-type calcium channel blocker with reduced off-target hERG toxicity, we modified the structure of the original compound by introducing a zwitterion and reducing the basicity of the nitrogen. Among the structurally modified compounds we designed, compounds 5 and 6, which incorporate amides in place of the original compound’s amines, most appreciably alleviated hERG toxicity while maintaining T-type calcium channel blocking activity. Notably, the benzimidazole amide 5 selectively blocked T-type calcium channels without inhibiting hERG (hERG/T-type ? 220) and L-type channels (L-type/T-type = 96), and exhibited an excellent pharmacokinetic profile in rats.
We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 58333-75-8, and how the biochemistry of the body works.Synthetic Route of 58333-75-8
Reference：
Piperidine – Wikipedia,
Piperidine | C5H12775N – PubChem