With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.187834-88-4,1-Boc-isonipecoticacidhydrazide,as a common compound, the synthetic route is as follows.
3-phenyl-2-(4-{ [4-(5-pyrimidin-2-yl-1H-1,2,4-triazol-3-yl)piperidin-1-yl]methyl} phenyl)-l,6-naphthyridin-5(6H)-one hydrochloride (6-54) 2-(3-piperidin-4-yl-lH-l,2,4-triazol-5-yl)pyrimidine (B)A mixture of tert-butyl 4-(hydrazinocarbonyl)piperidine-1-carboxylate (10.1 g, 41.5 mmol) and 2-cyanopyrimidine (4.36 g, 41.5 mmol) in 1-butanol (20 mL) was heated to reflux for 48 hours. The mixture was concentrated, suspended in ether, and filtered to give tert-butyl 4-(5-pyrimidin-2- yl-1H-1,2,4-triazol-3-yl)piperidine-1-carboxylate as a solid. MS (M+Eta1″): 331.2 observed; 1H-NMR (400 MHz, CD3OD): delta 8.92 (d, J=4.0Hz, 2H), 7.52 (t, J=4.0Hz, IH), 4.18-4.15 (m, 2H), 3.14-3.08 (m, IH), 2.98 (br.s, 2H), 2.07-2.01 (m, 2H), 1.85-1.77 (m, 2H), 1.48 (s, 9H)., 187834-88-4
The synthetic route of 187834-88-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; MERCK & CO., INC.; WO2006/65601; (2006); A2;,
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