With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.103816-19-9,[1,4′-Bipiperidine]-1′-carbonyl chloride,as a common compound, the synthetic route is as follows.
Embodiment of the Invention Preparation Examples Preparation Example 1; Preparation of 10-((4′-piperidylpiperidine)carbonyloxy)-9-allylcamptothecin(CPT-4); One gram (1.25 equivalent weight) of piperidylpiperidine chloroformic acid amide (compound 8) was dissolved in 70mL of dichloromethane, 10-hydroxy-9-allylcamptothecin (1g, 1 equivalent weight) was dissolved in 70mL of anhydrous pyridine, and then the above dichloromethane solution was added into the anhydrous pyridine solution under cooling condition. After the reaction was completed, the solvent was evaporated under reduced pressure. The residue was subjected to silica gel column chromatography, and 1.25g of CPT-4 yellow solid was obtained. 1HNMR (DMSO-d6) (ppm) : 1.01 (3H, t), 1.58?1.90 (10H, m), 1.80?1.99 (2H, m), 2.89 (4H, b), 3.09 (1H, b), 3.71 (2H, d), 4.45 (2H, dd), 4.94 (1H, dd), 5.11 (1H, dd), 5.14 (2H, s), 5.15 (1H, d), 5.66 (1H, d), 6.00 (1H, m), 7.47 (1H, d), 7.65 (1H, s), 8.11 (1H, d), 8.51 (1H, s).
103816-19-9, The synthetic route of 103816-19-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Shanghai Institute of Materia Medica, Chinese Academy of Sciences; EP1995249; (2008); A1;,
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