With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.92197-36-9,1-Benzyl-4-(hydroxymethyl)piperidin-4-ol,as a common compound, the synthetic route is as follows.
92197-36-9, step 1 4- (hydroxymethyl) piperidin-4-ol hydrochloride1-benzyl-4- (hydroxymethyl) piperidin-4-ol 500 mg (J. Med. Chem., was dissolved in ethanol 10ml synthesis) according to 1988,486-491, 10% palladium-carbon 300mg and concentrated hydrochloric acid 0.38ml was added and overnight hydrogenated at room temperature.Insoluble matter was separated by filtration, and washed with ethanol and water, and the filtrate was concentrated under reduced pressure.To the residue was powdered addition of diethyl ether, the desired product was obtained 374mg as a white powder.
As the paragraph descriping shows that 92197-36-9 is playing an increasingly important role.
Reference£º
Patent; NIPPON SHINYAKU COMPANY LIMITED; FUJIHARA, HIDETAKA; ASAKI, TETSUO; HORI, KATSUTOSHI; NAITO, HARUNA; (146 pag.)JP5668756; (2015); B2;,
Piperidine – Wikipedia
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