A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, Application In Synthesis of Ethyl 4-Oxo-3-piperidinecarboxylate Hydrochloride, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 4644-61-5, Name is Ethyl 4-Oxo-3-piperidinecarboxylate Hydrochloride, molecular formula is C8H14ClNO3. In a Article, authors is Zhang, Yong，once mentioned of 4644-61-5
A novel series of 4-arylamino-6/7-substituted-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidines were designed, synthesized and their biological activities as the potential anti-proliferative agents and EGFR kinase inhibitors were evaluated. Both of N-acrylamide fragment in THPPs and 4-aniline groups with substituents played key roles for their significant anti-proliferative activities against four cancer cell lines (HT29, A549, H460 and H1975). Especially inhibitory activity of Gefitinib-resistant H1975 were showed more favorable, which could be observed from compounds 13b, 13c, 13n, 13o, 13p, 13r, 13s, 13u and 24c obviously. By evaluation of inhibiting EGFR and HER2 kinases, seven compounds (13b, 13g, 13n, 13o, 13p, 13r and 13s) showed stronger EGFR potency with IC50 ? 18 nM, which could also be understood by preliminary docking study of 13b with EGFR kinase. In view of the primary SAR, bisarylaniline derivatives (13o, 13p, 13r and 13s) showed obvious improvements on HER2 inhibition, which indicated their being potential EGFR/HER2 dual kinase inhibitors.
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Reference：
Piperidine – Wikipedia,
Piperidine | C5H15581N – PubChem