With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.116574-71-1,tert-Butyl 3-(hydroxymethyl)piperidine-1-carboxylate,as a common compound, the synthetic route is as follows.
Sodium hydride (67 mg, 1.67 mmol) was added to tert-butyl 3- (hydroxymethyl)piperidine- 1 -carboxylate (CAS: 116574-71-1; 300 mg, 1.4 mmol) in DMF (10 mL) at 0 ¡ãC. The mixture was allowed to warm to rt and it was further stirred for 30 mm. Then the mixture was cooled again to 0 ¡ãC and 4-bromo-2,6- dimethylpyridine (CAS: 5093-70-9; 285.2 mg, 1.53 mmol) was added. The mixture was stirred at rt overnight. Water was added and the mixture was extracted withEtOAc. The organic layer was dried over MgSO4, filtered and evaporated under vacuum. The residue thus obtained was purified by flash column chromatography (Si02 EtOAc in heptane, 0/100 to 80/20) and the desired fractions were concentrated in vacuo affording intermediate 22 (65 mg, 16percent yield).
116574-71-1 tert-Butyl 3-(hydroxymethyl)piperidine-1-carboxylate 2763851, apiperidines compound, is more and more widely used in various.
Reference£º
Patent; JANSSEN PHARMACEUTICA NV; BARTOLOME-NEBREDA, Jose, Manuel; TRABANCO-SUAREZ, Andres, Avelino; ALCAZAR-VACA, Manuel, Jesus; MARTINEZ VITURRO, Carlos, Manuel; TRESADERN, Gary, John; ZHANG, Wei; CHEN, Gang; (212 pag.)WO2018/109202; (2018); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem