With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7462-86-4,Methyl piperidine-4-carboxylate hydrochloride,as a common compound, the synthetic route is as follows.
7462-86-4, EXAMPLE II The purpose of this example is to demonstrate one method for the preparation of a piperidinyl intermediate of Formula III. To a stirred, room temperature, mixture of isonipecotic acid methyl ester hydrochloride (5.00 g, 2.78*10-2 mole), potassium carbonate (7.70 g, 5.57*10-2 mole), and DMF (100 ml) was added 1-(2-bromoethyl)-4-methoxybenzene (5.99 g, 2.78*10-2 mole). The reaction was then immersed in an oil bath which had been preheated to ca. 90 C. The reaction was heated at ca. 90 C. for ca. 17 hours and was then poured into a separatory funnel containing water and a 2:1 mixture of ethyl acetate:toluene. The two phases were mixed and the aqueous layer was separated. The organic layer was washed two times with H20 and once with saturated aqueous NaCl before being dried over anhydrous Na2 SO4. The drying agent was removed by filtration and the filtrate was evaporated at reduced pressure leaving an oil. Purification by flash chromatography (ethyl acetate) and crystallization from cyclohexane gave 1-[2-(4-methoxyphenyl)ethyl]-4-piperidinecarboxylic acid, methyl ester as a colorless solid: 3.98 g (52%), m.p. 66-68 C. Analysis Calculated for C16 H23 NO3: C, 69.29; H, 8.36, N, 5.05. Found: C, 69.50; H, 8.40; N, 4.94.
As the paragraph descriping shows that 7462-86-4 is playing an increasingly important role.
Reference£º
Patent; Merrell Dow Pharmaceuticals Inc.; US4908372; (1990); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem