With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.116574-71-1,tert-Butyl 3-(hydroxymethyl)piperidine-1-carboxylate,as a common compound, the synthetic route is as follows.
Compound A1 generates A2 catalyzed by di-tert-butyl dicarbonate.Under the catalysis of oxalyl chloride and diisopropylethylamine,Under ultra-low temperature conditions,The mixture of dimethyl sulfoxide and methylene chloride reacts to form A3.And then in the al and a2 catalysis under the reflux of ethanol in hydrochloric acid to produce A4,A4 generates A5 at room temperature in aqueous sodium hydroxide solution.A6 is refluxed at room temperature in a solution of sodium borohydride in ethanol,In dichloromethane,The formation of A7 is catalyzed by a3, 1-hydroxybenzotriazole and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide.A8 is formed in dichloromethane with trifluoroacetic acid,A9 catalyzes the formation of A9 in dichloromethane.
As the paragraph descriping shows that 116574-71-1 is playing an increasingly important role.
Reference£º
Patent; Han Bing; Wang Shuang; Wang Lan; (14 pag.)CN104119339; (2018); B;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem