Related Products of 214147-48-5, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 214147-48-5, Name is 1-(4-Aminopiperidin-1-yl)ethanone hydrochloride, molecular formula is C7H15ClN2O. In a Article，once mentioned of 214147-48-5
The evaluation of a series of aminoisoindoles as beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors and the discovery of a clinical candidate drug for Alzheimers disease, (S)-32 (AZD3839), are described. The improvement in permeability properties by the introduction of fluorine adjacent to the amidine moiety, resulting in in vivo brain reduction of Abeta40, is discussed. Due to the basic nature of these compounds, they displayed affinity for the human ether-a-go-go related gene (hERG) ion channel. Different ways to reduce hERG inhibition and increase hERG margins for this series are described, culminating in (S)-16 and (R)-41 showing large in vitro margins with BACE1 cell IC50 values of 8.6 and 0.16 nM, respectively, and hERG IC50 values of 16 and 2.8 muM, respectively. Several compounds were advanced into pharmacodynamic studies and demonstrated significant reduction of beta-amyloid peptides in mouse brain following oral dosing.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Related Products of 214147-48-5, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 214147-48-5, in my other articles.
Reference：
Piperidine – Wikipedia,
Piperidine | C5H10836N – PubChem