With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1892-22-4,3-Aminopiperidin-2-one,as a common compound, the synthetic route is as follows.
To a solution of 0.1 g of 6-chloro-2-(3,5-dimethyl-1H-pyrazol-1-yl)-N-(3-(trifluoromethyl) phenyl) pyrimidin-4-amine [0735] in acetonitrile was added 3-amino-2-piperidone [0562] (0.062 g, 0.543 mmol) and N,N-diisopropyl ethylamine. The reaction mixture was heated at 180 C. under microwave for 5 h. The reaction mixture was concentrated under reduced pressure to afford crude product which was purified by column chromatography using 40% ethyl acetate in pet ether to afford 0.038 g of 3-((2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-((3-(trifluoromethyl)phenyl)amino)pyrimidin-4-yl)amino) piperidin-2-one [0744], Compound 189 as a white solid. MS(M+1)+=446.2. 1H NMR (400 MHz, DMSO-d6) delta 9.52 (s, 1H), 8.55 (s, 1H), 7.69-7.66 (m, 2H), 7.47 (t, J=8.0 Hz, 2H), 7.23 (d, J=7.7 Hz, 1H), 6.05 (s, 1H), 5.82 (s, 1H), 4.43 (s, 1H), 3.17 (bs, 2H), 2.52 (s, 3H), 2.18 (s, 3H), 2.15-2.10 (m, 1H), 1.89-1.64 (m, 3H).
1892-22-4, The synthetic route of 1892-22-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Cadent Therapeutics, Inc.; Jefson, Martin R.; Keaney, Gregg F.; Larsen, Janus Schreiber; Lowe, III, John A.; McCall, John M.; (110 pag.)US2017/355708; (2017); A1;,
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