With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1174020-64-4,tert-Butyl 4-((1R,2S,5R)-6-hydroxy-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamido)piperidine-1-carboxylate,as a common compound, the synthetic route is as follows.
To a solution of the product of step 2 (1.455 g, 3.95 mmol; theoretical yield of step 2) in dry pyridine (30 mL) was added sulfur trioxide pyridine complex (3.2 g, 20.11 mmol) at room temperature under nitrogen. The resulting thick mixture was stirred over the weekend.The reaction was filtered and the white insoluble solids were washed well with dichloromethane. The filtrate was concentrated in vacuo. The residue was further azeotroped with toluene to remove excess pyridine to afford the title compound which was used without purification in the next step., 1174020-64-4
As the paragraph descriping shows that 1174020-64-4 is playing an increasingly important role.
Reference£º
Patent; MERCK & CO., INC.; WO2009/91856; (2009); A2;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem