Let’s face it, organic chemistry can seem difficult to learn. Especially from a beginner’s point of view. Like 34737-89-8, Name is 1-Benzyl-3-methylpiperidin-4-one. In a document, author is Romero-Ibanez, Julio, introducing its new discovery. Formula: C13H17NO.
Transition-Metal-Free Functionalization of Saturated and Unsaturated Amines to Bioactive Alkaloids Mediated by Sodium Chlorite
New approaches to the synthesis of alkaloids through the straightforward functionalization of C(sp(3))-H and C(sp(2))=C(sp(2)) bonds of simple five- and six-membered-ring N-heterocycles are highlighted. The direct functionalization of pre-existing N-heterocycles to advanced alkaloids intermediates is a chemical operation that commonly requires the intervention of transition or precious metals. Regardless the inherent unwanted waste production, the high economical cost of many transition-metal catalysts limits their use globally. Here, we account our efforts directed toward the synthesis of bioactive alkaloids under an economic and ecological fashion by using NaClO2 as the key activating or oxidizing reagent that substitutes the use of transition-metal catalysts. While undesired metal wastes are collected during the extraction process of a transition-metal-catalyzed reaction, innocuous NaCl is the commonly product waste when NaClO2 is employed in our chemical transformations. Beginning with the synthesis of 2,3-epoxyamides from allyl amines, we concluded with the functionalization of multiple and remote C(sp(3))-H and C(sp(3))-C(sp(3)) bonds in piperidine rings that enabled the preparation of important bioactive alkaloids. For the latter functionalization, a precise amount of co-oxidant reagent (NaOCl) and radical 2,2,6,6-tetramethylpiperidinyloxy (TEMPO) were needed.
I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 34737-89-8 help many people in the next few years. Formula: C13H17NO.
Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem