With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.189442-78-2,1-Boc-N-methoxy-N-methylpiperidine-3-carboxamide,as a common compound, the synthetic route is as follows.
A solution of tert-butyl 3 -(methoxy(methyl)carbamoyl)piperidine- I -carboxylate (1.0 g, 3.7mmol) in 5 ml of DCM was charged with 5 ml of TFA and stirred at room temperature for one hour. The mixture was then concentrated in vacuo and azeotroped twice with toluene. Theresidue was then diluted with 5 ml of THF and 5 ml of methanol and charged withpropionaldehyde (450 mg, 7.7 mmol) and Sodium Triacetoxyborohydride (1.6 g, 7.7 mniol).The mixture was then stirred at room temperature for one hour and concentrated in vacuo. Themixture was then diluted with ethyl acetate and water. The aqueous was discarded and the organic layer was washed once with water, dried over Na2SO4, filtered, and concentrated in vacuo. The residue was then purified by silica-gel chromatography (1 -10% MeOH in DCM) to afford the the title compound (600 mg, 73% yield).
189442-78-2, The synthetic route of 189442-78-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.; ALBRECHT, Brian, K.; COTE, Alexandre; GEHLING, Victor; HSIAO-WEI TSUI, Vickie; KIEFER, James, Richard, Jr.; LIANG, Jun; MAGNUSON, Steven; NASVESCHUK, Christopher, G.; PASTOR, Richard; ROMERO, F. Anthony; TAYLOR, Alexander, M.; ZHANG, Birong; (287 pag.)WO2016/112284; (2016); A1;,
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