Chemistry, like all the natural sciences, Quality Control of Sodium 3-acetyl-6-methyl-2,4-dioxo-3,4-dihydro-2H-pyran-3-ide, begins with the direct observation of nature— in this case, of matter.4418-26-2, Name is Sodium 3-acetyl-6-methyl-2,4-dioxo-3,4-dihydro-2H-pyran-3-ide, SMILES is O=C(C=C(C)O1)[C-](C(C)=O)C1=O.[Na+], belongs to piperidines compound. In a document, author is Lennox, Alastair J. J., introduce the new discover.
Electrochemical Aminoxyl-Mediated alpha-Cyanation of Secondary Piperidines for Pharmaceutical Building Block Diversification
Secondary piperidines are ideal pharmaceutical building blocks owing to the prevalence of piperidines in commercial drugs. Here, we report an electrochemical method for cyanation of the heterocycle adjacent to nitrogen without requiring protection or substitution of the N-H bond. The reaction utilizes ABNO (9-azabicyclononane N-oxyl) as a catalytic mediator. Electrochemical oxidation of ABNO generates the corresponding oxoammonium species, which promotes dehydrogenation of the 2 piperidine to the cyclic imine, followed by addition of cyanide. The low-potential, mediated electrolysis process is compatible with a wide range of heterocyclic and oxidatively sensitive substituents on the piperidine ring and enables synthesis of unnatural amino acids.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 4418-26-2. Quality Control of Sodium 3-acetyl-6-methyl-2,4-dioxo-3,4-dihydro-2H-pyran-3-ide.
Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem