In an article, author is Peschiulli, Aldo, once mentioned the application of 120-73-0, Name: Purine, Name is Purine, molecular formula is C5H4N4, molecular weight is 120.11, MDL number is MFCD00079221, category is piperidines. Now introduce a scientific discovery about this category.
3,3-Difluoro-3,4,5,6-tetrahydropyridin-2-amines: Potent and permeable BACE-1 inhibitors
Since its discovery in 1999, BACE-1, a membrane anchored aspartyl protease expressed primarily in the CNS, has been the target of numerous medicinal chemistry research programs. These efforts have produced highly potent inhibitors with nanomolar affinity and ever-increasing structural complexity. However, only a handful of these molecules have been able to combine in vitro potency with CNS permeability and progressed to the clinic. Herein, we describe a set of novel piperidine-based inhibitors. This investigation culminated with the identification of 43, a highly potent (IC50 : 1.5 nM), permeable BACE-1 inhibitor with a low susceptibility to Pgp-mediated efflux.
If you are interested in 120-73-0, you can contact me at any time and look forward to more communication. Name: Purine.
Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem