With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.625471-18-3,(S)-tert-Butyl 3-aminopiperidine-1-carboxylate,as a common compound, the synthetic route is as follows.
(S)-tert-butyl 3-(l ‘-oxo-2 ‘ ,3 ‘-dihydro- 1 -spiro [cyclobutane- 1 ,4 ‘-pyrazino [1 ,2- a]indol]-7′-ylcarboxamido)piperidine-l-carboxylate (1): To a mixture of -oxo-2′,3′-dihydro- H-spiro[cyclobutane-l,4′-pyrazino[l,2-a]indole]-7’-carboxylic acid (intermediate 7, Example 78; 150 mg, 0.55 mmol) and (S)-tert-butyl 3-aminopiperidine-l-carboxylate (111 mg, 0.55 mmol) in dry DMF (5.0 mL) were added DMAP (169 mg, 1.38 mmol) followed by EDCI.HC1 (213 mg, 1.11 mmol). The resultant reaction mixture was stirred at room temperature under nitrogen atmosphere for 14 h. The reaction mixture was diluted with ice water (50 mL) and extracted with EtOAc (2 x 50 mL). The combined organic layers were further washed with brine solution (20 mL), dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography to obtain 1 (190 mg, 76percent) as white solid. 1H NMR (500 MHz, DMSO-d6): delta 1.37 (s, 9H), 1.45 (m, 2H), 1.60 (m, 1H), 1.73 (m, 1H), 1.90 (m, 1H), 2.07 (m, 3H), 2.30 (m, 2H), 2.98 (m, 2H), 3.70 (m, 3H), 3.81 (m, 2H), 7.13 (s, 1H), 7.63 (d, J = 8.0 Hz, 1H), 7.74 (d, J = 8.5 Hz, 1H), 8.30 (m, 2H), 8.35 (s, 1H). MS m/z (M+H): 453.0
625471-18-3, 625471-18-3 (S)-tert-Butyl 3-aminopiperidine-1-carboxylate 1501975, apiperidines compound, is more and more widely used in various fields.
Reference£º
Patent; CELGENE AVILOMICS RESEARCH, INC.; ALEXANDER, Matthew David; MCDONALD, Joseph John; NI, Yike; NIU, Deqiang; PETTER, Russell C.; QIAO, Lixin; SINGH, Juswinder; WANG, Tao; ZHU, Zhendong; WO2014/149164; (2014); A1;,
Piperidine – Wikipedia
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