Application of 105812-81-5, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 105812-81-5, Name is (3S,4R)-4-(4-Fluorophenyl)-3-hydroxymethyl-1-methylpiperidine, SMILES is CN1C[C@@H](CO)[C@H](C2=CC=C(F)C=C2)CC1, belongs to piperidines compound. In a article, author is Dorostkar-Ahmadi, Nadieh, introduce new discover of the category.
1,8-Diazabicyclo [5.4.0]undec-7-ene Catalyzed Synthesis of Some New 7-Alkyl-6-oxo-1H-pyrazolo[3,4-b]pyridine-5-carbonitriles
Starting from 5-chloro-1,3-diphenyl-1H-pyrazole-4-carbaldehyde, the synthesis of some new bicyclic 7-alkyl-6-oxo-1,3-diphenyl-6,7-dihydro-1H-pyrazolo[3,4-b]pyridine-5-carbonitriles catalyzed by 1,8-diazabicyclo [5.4.0] undec-7-ene (DBU) is described. Knoevenagel condensation reaction of 5-chloro-1, 3-diphenyl-1H-pyrazole-4-carbaldehyde with ethyl cyanoacetate in refluxing ethanol containing a few drops of piperidine afforded the (Z)-ethyl 3-(5-chloro-1,3-diphenyl-1H-pyrazol-4-yl)-2-cyanoacrylate. Treatment of this compound with primary alkyl amines in the presence of DBU as a catalyst in dimethylformamide at reflux temperature gave new 7-alkyl-6-oxo-1,3-diphenyl-6,7-dihydro-1H-pyrazolo[3,4-b]pyridine-5-carbonitriles in high yields. All synthetic compounds were characterized on the basis of their spectral and microanalytical data. The correct stereoisomer of the Knoevenagel product was confirmed with comparison of the experimental and calculated H-1 nuclear magnetic resonance (NMR) and C-13 NMR chemical shifts using density functional theory calculations at the B3LYP/6-31+G(d,p) level of theory. [GRAPHICS] .
Application of 105812-81-5, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 105812-81-5 is helpful to your research.
Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem