287952-67-4, 4-(4-Trifluoromethoxyphenoxy)piperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Add 20 mL of dichloromethane to 2-chloro-3-nitro-5-trifluoromethylbenzoic acid (12 mmol), stir at room temperatureOxalyl chloride (30.5 mmol) and 0.05 mL of DMF were slowly added dropwise and reacted for two hours.After the reaction was completed, the reaction solution was spoked, dissolved in 15 mL of dichloromethane, and slowly added dropwise with ammonium thiocyanate (36 mmol).Add PEG-400 (0.2g), stir at room temperature for 1.5 hours; filter,The filtrate was added dropwise to a solution of 4-(2-fluoro-4-methylphenoxy)piperidine in dichloromethane, and stirred at room temperature for 40 min.After the reaction is completed, the reaction solution is spun dry, column chromatography,Obtained yellow solid 1i, yield 54%.
The synthetic route of 287952-67-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Sichuan University; Yu Luoting; Wei Yuquan; Gao Chao; (52 pag.)CN108456204; (2018); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem