With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.143900-44-1,(S)-tert-Butyl 3-hydroxypiperidine-1-carboxylate,as a common compound, the synthetic route is as follows.
(S)-tert-butyl 3-(tosyloxy)piperidine-1-carboxylate: To a stirred solution of (S)-tert-butyl 3-hydroxypiperidine-1-carboxylate (50 g, 1.0 eq), TsC1 (4-methylbenzene-1- sulfonyl chloride, 52 g, 1.1 eq) and DMAP (4-dimethylamiopryidine, 2.5g) in 500 mL CH2C12 at 0 C was added Et3N (51 g, 2.0 eq). After addition was completed, the reaction mixture was warmed to r.t. and stirred at that temperature for 40 hours. The organic layer was washed with water and brine, dried with anhydrous Na2SO4, and purified by flash chromatography to give the product as a white solid (80 g, 9 1%). ?H NMR (400 MHz, CDC13) oe 7.80 (d, J = 8.0 Hz, 2H), 7.34 (d, J = 8.0 Hz, 2H), 4.46 (brs, 1H), 3.54-3.58 (m, 1H), 3.31-3.40 (m, 3H), 2.45 (s, 3H), 1.80-1.88 (m, 1H), 1.65-1.79 (m, 2H), 1.47-1.52 (m, 1H), 1.43 (s, 9H).
143900-44-1, The synthetic route of 143900-44-1 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; CENTAURUS BIOPHARMA CO., LTD.; HAN, Yongxin; YU, Rong; WANG, Zanping; LIANG, Zhi; HU, Quan; ZHU, Li; HU, Yuandong; SUN, Yinghui; ZHAO, Na; PENG, Yong; ZHAI, Xiaofeng; LUO, Hong; XIAO, Dengming; WO2014/82598; (2014); A1;,
Piperidine – Wikipedia
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